UK Study Casts Doubt on Testosterone Therapy for Depressed Type 2s
A British study of type 2 men reports that although testosterone therapy had a beneficial effect on blood glucose levels and other metabolic indicators for non-depressed men, those suffering from depression experienced no benefit.
Hackett’s study, which involved 200 type 2 men with hypogonadism, set out to see if treating patients for low testosterone would have any effect on depression. Hackett and his colleagues tracked the patients over a 30-week study, then followed up with half of them for another 52 weeks.
Going into the study, 23 percent of the type 2 men had been diagnosed as depressed. The researchers noted that this group tended to be younger and more obese than the other type 2 patients.
Treatment consisted of 1,000 mg doses of testosterone undecanoate administered at the start of the study and at Weeks 6 and 18. A control group received placebo. Non-depressed participants enjoyed “significantly reduced” A1C levels and weight reduction, but none of the depressed participants saw any improvement in those measures.
According to Hackett, a preliminary conclusion from the study is that type 2 men who are eligible for testosterone therapy should be tested for depression before undergoing a treatment that may not benefit them.
The study was presented at a conference and has not yet been published in a peer-reviewed journal.